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Renewed death after HPV vaccination Another unexplained death, the debate about the safety of the HPV vaccine has given new impetus: In Britain, a fourteen-year-old girl died a day after she had received the vaccine in the national immunization program in primary schools. With three other classmates, vaccination should have caused nausea and dizziness. The affected batch of vaccine was "precautionary" collected by the National Health Service NHS. But it could also be "no connection between the death and the vaccine will be made unless all the facts are present and there has been an autopsy, " said a representative of the NHS. The vaccine manufacturer GlaxoSmithKline said his "deepest sympathy" and announced its willingness to cooperate in the investigation of the case with the British Ministry of Health and the national regulatory authority for medical devices MHRA. Even without this serious incident would be a re-evaluation of vaccination and the last spring hastily introduced national immunization program in British schools: 2, 000 reports of suspected adverse reactions to the MHRA have since been reported over 400 times, it should have come to an anaphylactic shock. In the U.S., each one death in temporal association with vaccination have been since the introduction of the vaccine Gardasil several reported in Germany and Austria. Critics describe the introduction of vaccination, given the meager data available on its safety and efficacy as premature and irresponsible. The UK has admitted the only European country the vaccine Cervarix by GlaxoSmithKline (and not Gardasil, Sanofi Pasteur) for this product, the available data should even be "still unsatisfactory". ( , 29.09.09; , 29.09.09; article "A year HPV vaccination" of Thonke Seyler in GID 187; drug telegram 2007 Jg.38, no .11) (mf) Romania / Israel: Illegal Eizellhandel Because Eizellhandel, organized crime and the exercise of medical activities without approval of a special unit of the Romanian Police has arrested three doctors against organized crime in the Bucharest Sabyc IVF clinic and asked another thirty people under house arrest. The clinic is under the direction of an Israeli gynecologist had without authorization more than 1, 200 IVF cycles performed in German, Israeli, British and Italian clients who had paid 10, 000 to 15, 000 euros per IVF treatment. Particular attention cried out that the clinical team had campaigned for women banned in Romania Eizellverkauf. Per cycle, according to newspaper reports 130-280 euros were paid. The eggs were from students and from Roma women, some of whom were only fifteen years old. Egg donation in Israel is the women who did not undergo IVF treatment itself, is prohibited. A legislative reform to allow unpaid egg donation, was initially put on hold after these incidents. This was already insufficient, the feminist organization Isha L'Isha, Haifa. "We object that the children need is met by the plight of other women being exploited." Indispensable are mainly international cooperation to control the Eizellhandels and "other non-exploitative opportunities for those seeking the way out of their financial difficulties in Eizellhandel Search ". (BioNews, 3:08:09; , 20:08:09; ) (sus) Of true parents and surrogate mothers involuntary Even if it is not so far away with births in reproductive medicine: new concepts and language combinations it produces again and again. As a "victim of embryo confusion" was recently Carolyn Savage from the U.S. state of Ohio referred to in the press. She had IVF treatment to make in February, when it accidentally, the fertilized egg of another woman was transferred. Focus Online headline will be: "Finally pregnant - but with the wrong embryo." After doctors had informed her, Savage decided to continue the pregnancy and has been - at least for the Medical Journal - the "involuntary surrogate mother." Now she has passed the "real" parents, the recently born baby, this is for all media throughout the couple from whom came the germ cells. About the CNN Savage then congratulated the family and asked the media to restraint. Their family, the mother of three, go "through a very difficult time" (Focus Online, 23.09.09; Medical Journal, 28/09/09). (Uw) USA: donor sperm as of Stars Ever since the establishment of the Nobel Sperm Bank in the 1980s is well known that assisted reproduction and desire for the "perfect" baby often go hand in hand. Then offered the cheap U.S. sperm bank sperm of Nobel Prize winners and promised that unsaid to share their intelligence and success with their genes. Meanwhile, the Nobel Sperm Bank - allegedly due to lack of demand - received, but a California company now offers a similar service to delicate: Seeds are categorized by the similarity of their donors with stars. Under the menu item "donor look-a-likes" clients can be located beside personal information about individual donors also the photos of three actors or other famous people watch, which they resemble. For the longer-term family planning, the donor sperm - surcharge - to be reserved several years in personal vaults. (Biopolitical Times, 30/09/09; ) (mf) DNA evidence is not falsification DNA evidence can be faked easily. "A basic and basic knowledge" sufficient to introduce DNA in blood or saliva, and these traces' to deposit at crime scenes, as Israeli researchers in the announcement of its publication. Not only can existing 'natural' DNA are used, but also synthetically . Specifically produced had provided blood and saliva samples of a man with the DNA of a woman's scientists. Other samples, they visited out with DNA profiles, which they had prepared synthetically. For this they used DNA snippets of various profiles from police DNA databases and combined . they These fakes were not detected in different laboratories using the current methods of DNA testing new For those of various commentators "worrying" called problems, the researchers have, however, already have a solution., you are working on a test between can distinguish natural 'and artificial samples. Such a test procedure was "necessary to maintain the high credibility of DNA evidence in the legal system upright." Apart from the question whether this is desirable, there is a certain piquancy that three of four scientists to biotech start-up Nucleix belong, which is market the test and the fourth researcher is a unit of the Israeli police - which also raises a question.? Those who had actually why the idea of ​​DNA evidence to falsify ( Forensic Science International: Genetics Online, 16:07:09, SZ, 18 and 20:08:09) (uw) Forgery by gene manipulation A highly regarded publication in Nature Genetics in 2003 has now been revoked by the editors of the journal. The more than 180 times cited study, which was conducted as part of the sponsored, among others, nearly one million of public funds international cooperation project "Molecular Analysis of genetically complex epilepsies" had come to the conclusion that a specific DNA change triggers epilepsy. This assertion was the result of a forgery. Neurologist Armin H. had data of the investigated families manipulated massively As the director of the Bonn University Clinic of Epileptology, Christian Elger, compared with the levels reported, had been initiated in 2007 to review the study results was Noticed ago. all their uniqueness: A correlation between the mutation described and the incidence of epilepsy was also observed in other studies, however, were never all mutation carriers suffer also from epilepsy The renewed investigation revealed that one of the three families mentioned in the study, only three. instead claimed five people wore the mutation and only one of these three people had fallen ill -. publication had all five listed as epileptics In the second family of eight persons were two instead of claiming false allegations of ill The editors of the journal Nature Genetics Been. . known for a year, says Markus Nöthen, Vice Dean for Research at the Medical Faculty of the University of Bonn why the publication has only now been revoked, it is not clear that are involved in the study, 25 scientists subjected the study also back -. except for Armin H . (online time, 16:09:09, the mirror 38/2009) (uw) Similar sperm cells were Plagiarism A scientific publication on the production of artificial sperm from embryonic stem cells in the journal Stem Cells and Development has been withdrawn by the publisher Graham Parker (see GID 195, p 33). Parker basing its decision on the accusation of plagiarism: two paragraphs in the article had been copied from an earlier article in the same journal, without having to indicate this. Doubt on the scientific statements in the article were unfounded however. However, the criticism of the article was about the accusation of plagiarism beyond. Different voices have criticized the "over-hyping" and is related to how the product was marketed. Both the title of the article and the accompanying press release had suggested that there had actually acted in the cells produced by Karim Nayernia in Newcastle from embryonic stem cells to sperm cells. The text itself, however, speak only of "sperm-like cells" and "tail-like structures." (BioNews, 03:08:09) (sus) Geron trial stopped The world's first approved clinical experiment with a drug made from embryonic stem cells was stopped in mid-August before the first subject is thus came into contact. The biotech company Geron had received a grant for the experiments with the drug GRNOPC1 until January. Now that self-presented by the company studies had shown that very often cysts had formed in experimental animals in the last series of tests, ordered the U.S. Drug and Food Administration FDA to delay the clinical trials to evaluate these results. Geron pointed out that the cysts do not scattered, it is not so play to cancerous tumors. The shares of the biotech company recorded a message after the price decline of 14 percent. The Geron experiment in which eight to ten spinal cord injuries are involved, apply for stem cell research as a crucial moment in order to continue to receive the hype about embryonic stem cells can be maintained - or not. (AP, 18:08:09; NYTimes, 19:08:09; BioNews, 06:09:09) (sus)
China: iPS Klonmäuse First two research groups from reprogrammed skin cells called iPS cells, have bred mice. The researchers used the method introduced by the Japanese scientist Shinya Yamanaka, means of introducing four genes into the DNA of skin cells so as to "reprogram" that they assume characteristics of an embryonic stem cell. In Cell Stem Cell, the team of Shaorong Gao from the National Institute of Biological Sciences in Beijing said that it had bred five mice from iPS cells, of which only one animal survived until it was grown. The team led by Xiao-yang Zhao of the Beijing Academy of Sciences announced at the same time in his publication in Nature, about 27 have bred mice. Of these 27 mice, some have remained healthy and had already hundreds of offspring. Others died early and / or reported malformations. The method is to inject the iPS cells into tetraploid embryos created specifically for this case, the transform only in the placenta and other necessary for the development of cells, but not in somatic cells. The 27 mice developed from embryos 661 produced in this way. Emphasizes the scientists reacted calmly community on the result: Mice were bred with the same long, standard methods used in China from embryonic stem cell lines, such as Jeanne Loring of the Scripps Institute in California. This seems calm but placed in view of the importance of these experiments. Although the iPS Klonmäuse represent no technology innovation - for the public, they make it very clear how credible are the currently established bioethical criteria: The argument that the research on iPS cells is "ethical" as embryo research, in which moment of absurdity when iPS cells from cloned embryos in turn be made. (DW-World.de, 24.07.09, Time, 27/07/09; BioNews, 27.07.09) (sus) 23andMe: Discount for revolutionaries Two U.S. companies offering commercial genetic testing on the Internet, have come to a new sales idea: Who declared its willingness to provide the information on personal health and their own DNA samples overall for research projects available to get at TruGenetics a Gencheck for nothing at 23andMe it costs "only" $ 99 - regularly have people who want to determine their health risks via genetic testing, pay for 400 U.S. dollars. However, the action is more than a pure business model. At least the customers of 23andMe always automatically give their consent for the use of their samples and data for research purposes: Under the heading "core values" can be found on the website formulated a cumbersome approval. New is the aggressive promotion by participating in a "research revolution" that appeals in addition to the self-interest and altruism of customers. (BioNews, 26/07/09; , 28/07/09) (uw) China: Direct-the-consumer tests? Since the summer of this year, commercial genetic test providers can also be used in China Products: For the equivalent of about 880 U.S. dollars parents can send their child for five days in a kind of summer camp where their DNA is tested to provide information about their talents and gifts to receive. The test performs a biotech start-up from Shanghai. In addition, scientists observe the children in sports, music and art. The results of the tests result in a recommendation for the parents, what activities should follow their child especially. "Today will compete for the best talent, " comments the director of the facility, Zhao Mingyou. "We can give Chinese children at an early date an effective, scientific plan." Demand for such, plans' should be relatively easy to carry with its one-child policy in China - at least in more affluent parents. ( , 19:08:09) (uw) Breast cancer: epi-Genetifizierung The observed recently statistical correlations between changes in DNA and the occurrence of breast cancer are still loose: So now an international study of 2, 500 breast cancer patients has shown that the so-called ATM gene - the part in the repair 'of DNA damage, 'is - a "zuzukommen much more important role in the development of breast cancer [seems] than previously thought." The focus of further research would therefore be on the "identification of additional genetic and environmental factors, " "influence the risk of breast cancer ATM mutation carriers." A genetic mutation that allowed such a high probability statement such as changes in the two breast cancer genes known as BRCA 1 and 2 is therefore not in sight. Because only about one-third of all women with breast cancer, in whom the disease in the family is very common, even a BRCA 1 or 2 mutation is found, geneticists are looking for other DNA segments for several years, correlate with the accumulated occurrence of breast cancer. (Idw Online, 25.09.09) (uw) Compared to ten million base pairs Chris Tyler-Smith of the Wellcome Trust Sanger Institute in Cambridge and his colleagues will have found out how many mutations are found in a single human being. Your analysis of the base pairs of the Y chromosome of two men who were already used in the thirteenth generation together, showed that per-generation is changed from 15 to 30 million nucleotides. From this they deduced that each person has 100 to 200 DNA alterations. For this calculation a huge amount of data has been generated - ten million base pairs were studied. The result, however, is less dramatic: In 1935 came the geneticist Haldane, in a study of people with a hereditary blood disease similar results. (Focus Online, 28.08.09) (uw) DFG-funded biopolitics On traditional in the field of biopolitics University of Münster, the German Research Foundation (DFG) establishes a new college-research group. The project "Theoretical issues of justification of norms in medical ethics and biopolitics" is replaced in the next four years, around 4.6 million euros, and has, as it is nebulous, "Processes of formation and justification of medical ethics, -legal and bio-political norms, " ​​the subject. The rationale for promoting the DFG will be a little clearer: ethical problems that arise as a result of scientific and technical progress, in today's media society would quickly become matters of public debate. Since no common system of norms and values ​​exist more in Western societies, it would not be uncommon in a state of continuous normative debate. The funded project should therefore provide resources for the explanation and justification consensual moral and legal norms. ( 06:08:09) (uw)


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